16-P011 Wdr35 is required for mammalian ciliogenesis and Hh responsiveness
نویسندگان
چکیده
A novel role for notch signalling in left–right determination through ciliary length control Susana Lopes, Raquel Lourenc o, Luis Pacheco, Nuno Moreno, Jill Kreiling, Leonor Saúde 1 Instituto de Medicina Molecular, Lisbon, Portugal 2 Instituto de Histologia e Biologia do Desenvolviment da Faculdade de Medicina de Lisboa, Lisbon, Portugal 3 Instituto Gulbenkian de Ciência, Oeiras, Portugal 4 Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, United States
منابع مشابه
Human and mouse mutations in WDR35 cause short-rib polydactyly syndromes due to abnormal ciliogenesis.
Defects in cilia formation and function result in a range of human skeletal and visceral abnormalities. Mutations in several genes have been identified to cause a proportion of these disorders, some of which display genetic (locus) heterogeneity. Mouse models are valuable for dissecting the function of these genes, as well as for more detailed analysis of the underlying developmental defects. T...
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It has been a decade since it was discovered that primary cilia have an essential role in Hedgehog (Hh) signaling in mammals. This discovery came from screens in the mouse that identified a set of genes that are required for both normal Hh signaling and for the formation of primary cilia. Since then, dozens of mouse mutations have been identified that disrupt cilia in a variety of ways and have...
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The Hedgehog (Hh) signaling pathway plays a key role in cell fate specification, proliferation, and survival during mammalian development. Cells require a small organelle, the primary cilium, to respond properly to Hh signals and the key regulators of Hh signal transduction exhibit dynamic localization to this organelle when the pathway is activated. Here, we investigate the role of Cell Cycle ...
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عنوان ژورنال:
- Mechanisms of Development
دوره 126 شماره
صفحات -
تاریخ انتشار 2009